Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …

In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Menopause is associated with hormonal changes, which could accelerate or lead to
sarcopenia. Functional impairment and physical disability are the major consequences of …

A ketogenic diet (KD) has been promoted as an obesity management diet, yet its underlying
mechanism remains elusive. Here we show that KD reduces energy intake and body weight …

At least half of all patients with heart failure (HF) are affected by frailty, a syndrome that limits
an individual ability to recover from acute stressors. While frailty affects up to 90% of patients …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

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Importance The association between weight change and subsequent cause-specific
mortality among older adults is not well described. The significance of changes in waist …

Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …