Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group
of tumours about which little is known biologically, and whose diagnosis, on the basis of …

The molecular bases of brain development and CNS malignancies remain poorly
understood. Here we show that Sonic hedgehog (Shh) signaling controls the development …

Throughout life, neural stem cells (NSCs) in different domains of the ventricular-
subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of …

In the past, attempts to create a hierarchical classification of brain structures (an ontology)
have been limited by the lack of adequate data on developmental processes. Recent studies …

Sonic hedgehog (Shh) signal transduction via the G-protein-coupled receptor, Smoothened,
is required for proliferation of cerebellar granule neuron precursors (CGNPs) during …

Over the last century, several morphological models of forebrain organization have been
proposed that hypothesize alternative topological solutions for the relationships of the …

Hedgehog pathway activation is required for expansion of specific neuronal precursor
populations during development and is etiologic in the human cerebellar tumor …

The cerebellum is critical for motor coordination and cognitive function and is the target of
transformation in medulloblastoma, the most common malignant brain tumor in children …