The Philadelphia negative myeloproliferative neoplasms (MPN) compromise a
heterogeneous group of clonal myeloid stem cell disorders comprising polycythaemia vera …

Polycythemia vera (PV) is mainly characterized by elevated blood cell counts, thrombotic as
well as hemorrhagic predisposition, a variety of symptoms, and cumulative risks of fibrotic …

Thrombosis in the context of Cardiovascular disease (CVD) affects mainly the blood vessels
supplying the heart, brain and peripheries and it is the leading cause of death worldwide …

Thrombosis is common in cancer patients and is associated with increased morbidity and
mortality. Myeloproliferative neoplasms (MPN) are common malignancies in elderly …

Highlights•Defects in haemostasis can be regulated by aberrant epigenetic mechanisms.•
Reversible epigenetic changes in thrombotic complications are ideal drug …

Background Patients suffering from the BCR-ABL1-negative myeloproliferative disease
prefibrotic primary myelofibrosis (pre-PMF) have a certain risk for progression to …

Thrombosis is at the heart of cardiovascular complications observed in specific diseases. A
heightened thrombosis risk above that in general population in diseases such as …

Objective: Acute myeloid leukemia (AML) is a clonal malignant hematological neoplasm with
a poor prognosis and high heterogeneity. Many studies have been conducted on the …