Abstract Context Although prostate cancer (PCa) screening reduces the incidence of
advanced disease and mortality, trade-offs include overdiagnosis and resultant …

Abstract In 2009, the American Cancer Society (ACS) Prostate Cancer Advisory Committee
began the process of a complete update of recommendations for early prostate cancer …

Purpose: The guideline purpose is to provide the urologist with a framework for the early
detection of prostate cancer in asymptomatic average risk men. Materials and Methods: A …

Background After 11 years of follow-up, the European Randomized Study of Screening for
Prostate Cancer (ERSPC) reported a 29% reduction in prostate-cancer mortality among men …

Background The time by which prostate-specific antigen (PSA) screening advances prostate
cancer diagnosis, called the lead time, has been reported by several studies, but results …

Background Ovarian cancer has a high case–fatality ratio, with most women not diagnosed
until the disease is in its advanced stages. The United Kingdom Collaborative Trial of …

Primary biliary cirrhosis is a chronic liver disease characterised by intrahepatic bile-duct
destruction, cholestasis, and, in some cases, cirrhosis. Evidence supporting the autoimmune …

Objective To quantify the plausible contribution of prostate-specific antigen (PSA) screening
to the nearly 30% decline in the US prostate cancer mortality rate observed during the …

Prostate cancer has emerged as the most frequent cancer amongst men in Europe, with
incidence increasing rapidly over the past two decades. Incidence has been uniformly …

Objective To determine the optimal method for quantifying and monitoring overdiagnosis in
cancer screening over time. Design Systematic review of primary research studies of any …