The current developments in medicinal plant genomics enabled the diversification of secondary metabolites' biosynthesis

MM Alami, Z Ouyang, Y Zhang, S Shu, G Yang… - International journal of …, 2022 - mdpi.com
Medicinal plants produce important substrates for their adaptation and defenses against
environmental factors and, at the same time, are used for traditional medicine and industrial …

Natural products of medicinal plants: biosynthesis and bioengineering in post-genomic era

L Guo, H Yao, W Chen, X Wang, P Ye, Z Xu… - Horticulture …, 2022 - academic.oup.com
Globally, medicinal plant natural products (PNPs) are a major source of substances used in
traditional and modern medicine. As we human race face the tremendous public health …

A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane …

W Zhou, C Wang, X Hao, F Chen, Q Huang, T Liu… - Plant …, 2024 - cell.com
Tropane alkaloids (TAs), which are anticholinergic agents, are an essential class of natural
compounds, and there is a growing demand for TAs with anesthetic, analgesic, and …

A large-scale assessment of the quality of plant genome assemblies using the LTR assembly index

MM Mokhtar, HM Abd-Elhalim, A El Allali - AoB Plants, 2023 - academic.oup.com
Recent advances in genome sequencing have led to an increase in the number of
sequenced genomes. However, the presence of repetitive sequences complicates the …

Genomic and structural basis for evolution of tropane alkaloid biosynthesis

YJ Wang, T Tain, JY Yu, J Li, B Xu… - Proceedings of the …, 2023 - National Acad Sciences
The tropane alkaloids (TAs) cocaine and hyoscyamine have been used medicinally for
thousands of years. To understand the evolutionary origins and trajectories of serial …

Unlocking secrets of nature's chemists: Potential of CRISPR/Cas-based tools in plant metabolic engineering for customized nutraceutical and medicinal profiles

RM Shelake, AM Jadhav, PB Bhosale… - Plant Physiology and …, 2023 - Elsevier
Plant species have evolved diverse metabolic pathways to effectively respond to internal
and external signals throughout their life cycle, allowing adaptation to their sessile and …

Multiple independent losses of the biosynthetic pathway for two tropane alkaloids in the Solanaceae family

J Yang, Y Wu, P Zhang, J Ma, YJ Yao, YL Ma… - Nature …, 2023 - nature.com
Hyoscyamine and scopolamine (HS), two valuable tropane alkaloids of significant medicinal
importance, are found in multiple distantly related lineages within the Solanaceae family …

Compartmentalization at the interface of primary and alkaloid metabolism

JL Watkins, PJ Facchini - Current Opinion in Plant Biology, 2022 - Elsevier
Plants produce many compounds used by humans as medicines, including alkaloids of the
benzylisoquinoline (BIA), monoterpene indole (MIA) and tropane classes. The biosynthetic …

Applications of some advanced sequencing, analytical, and computational approaches in medicinal plant research: a review

D Singh, N Mittal, S Verma, A Singh… - Molecular Biology …, 2024 - Springer
The potential active chemicals found in medicinal plants, which have long been employed
as natural medicines, are abundant. Exploring the genes responsible for producing these …

The broad-scale accumulated and regulated patterns of leaf functional metabolites in two populations of the medicine-industrial plant Viola philippica

K Wang, X Chen, Z Liu, Y Mei, M Yang… - Industrial Crops and …, 2024 - Elsevier
Owing to the limited natural distributions and special medicine-industrial values of Viola
philippica, it's urgently needed to explore its population-level differences for promoting the …