Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

About 15% of patients with Parkinson disease (PD) have family history and 5–10% have a
monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Mitochondria are highly dynamic organelles and important for a variety of cellular functions.
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …

Although defects in intracellular calcium homeostasis are known to play a role in the
pathogenesis of Parkinson's disease (PD), the underlying molecular mechanisms remain …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting
1–1.5% of the total population. While progress has been made in understanding the …

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

Parkinson's disease (PD) is a debilitating movement disorder typically associated with the
accumulation of intracytoplasmic aggregate prone protein deposits. Over recent years …

Background PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in
mitochondria that is critical for mitochondrial quality control. PINK1 triggers mitophagy, a …