Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular
endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet …

The generation of an inflammatory environment is favorable and often decisive for the
growth of both primary tumors and metastases. Tumor cells either express membrane …

Soft tissue sarcomas (STSs) gather over 80 histological entities, with even more molecular
subsets, characterised by a low to very low incidence in all populations. The majority of …

Background Tenosynovial giant cell tumour (TGCT), a rare, locally aggressive neoplasm,
overexpresses colony-stimulating factor 1 (CSF1). Surgery is standard with no approved …

Macrophage infiltration has been identified as an independent poor prognostic factor in
several cancer types. The major survival factor for these macrophages is macrophage …

Background Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most
tenosynovial giant-cell tumors. This observation has led to the discovery and clinical …

Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur
almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location …

Background Diffuse-type tenosynovial giant cell tumour (dt-GCT) of the soft tissue
(alternatively known as pigmented villonodular synovitis), an orphan disease with unmet …

Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a
heterogenous mix of clinical and pathologic characteristics. STS can develop from fat …

Tenosynovial giant cell tumor (TSGCT) is a rare benign tumor arising from joint synovia,
bursae and tendon sheaths. Their variable clinical presentation is related to variations in site …