Cytoplasmic polyadenylation element binding proteins in development, health, and disease
M Ivshina, P Lasko, JD Richter - Annual review of cell and …, 2014 - annualreviews.org
The cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific
mRNA binding proteins that control translation in development, health, and disease. CPEB1 …
mRNA binding proteins that control translation in development, health, and disease. CPEB1 …
CPEB and translational control by cytoplasmic polyadenylation: Impact on synaptic plasticity, learning, and memory
YS Huang, R Mendez, M Fernandez, JD Richter - Molecular psychiatry, 2023 - nature.com
The late 1990s were banner years in molecular neuroscience; seminal studies
demonstrated that local protein synthesis, at or near synapses, was necessary for synaptic …
demonstrated that local protein synthesis, at or near synapses, was necessary for synaptic …
Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer's disease protects against mitochondrial dysfunction and mitigates brain …
A Verma, A Shteinfer-Kuzmine, N Kamenetsky… - Translational …, 2022 - Springer
Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …
The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3
Consolidation of long-term memories depends on de novo protein synthesis. Several
translational regulators have been identified, and their contribution to the formation of …
translational regulators have been identified, and their contribution to the formation of …
The wild species genome ancestry of domestic chickens
Background Hybridisation and introgression play key roles in the evolutionary history of
animal species. They are commonly observed within several orders in wild birds. The …
animal species. They are commonly observed within several orders in wild birds. The …
MicroRNA-92a–CPEB3 axis protects neurons against inflammatory neurodegeneration
I Winkler, JB Engler, V Vieira, S Bauer, YH Liu… - Science …, 2023 - science.org
Neuroinflammation causes neuronal injury in multiple sclerosis (MS) and other neurological
diseases. MicroRNAs (miRNAs) are important modulators of neuronal stress responses, but …
diseases. MicroRNAs (miRNAs) are important modulators of neuronal stress responses, but …
Loss of TREM2 confers resilience to synaptic and cognitive impairment in aged mice
W Qu, L Li - Journal of Neuroscience, 2020 - Soc Neuroscience
Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor exclusively
expressed by microglia in the brain, modulates microglial immune homeostasis. Human …
expressed by microglia in the brain, modulates microglial immune homeostasis. Human …
Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation
B Duran-Arqué, M Cañete, CL Castellazzi, A Bartomeu… - Genome Biology, 2022 - Springer
Background Vertebrate CPEB proteins bind mRNAs at cytoplasmic polyadenylation
elements (CPEs) in their 3′ UTRs, leading to cytoplasmic changes in their poly (A) tail …
elements (CPEs) in their 3′ UTRs, leading to cytoplasmic changes in their poly (A) tail …
CPEB3 low-complexity motif regulates local protein synthesis via protein–protein interactions in neuronal ribonucleoprotein granules
Biomolecular condensates, membraneless organelles found throughout the cell, play critical
roles in many aspects of cellular function. Ribonucleoprotein granules (RNPs) are a type of …
roles in many aspects of cellular function. Ribonucleoprotein granules (RNPs) are a type of …
The role of CPEB family proteins in the nervous system function in the norm and pathology
E Kozlov, YV Shidlovskii, R Gilmutdinov, P Schedl… - Cell & Bioscience, 2021 - Springer
Posttranscriptional gene regulation includes mRNA transport, localization, translation, and
regulation of mRNA stability. CPEB (c ytoplasmic p olyadenylation e lement b inding) family …
regulation of mRNA stability. CPEB (c ytoplasmic p olyadenylation e lement b inding) family …