Discovery and characterization of clinical candidate LXE408 as a kinetoplastid-selective proteasome inhibitor for the treatment of leishmaniases

A Nagle, A Biggart, C Be, H Srinivas… - Journal of Medicinal …, 2020 - ACS Publications
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments
have shortcomings that include toxicity and variable efficacy across endemic regions …

Serum Levels of Vitamins and Trace Elements in Patients with Visceral Leishmaniasis: a Systematic Review and Meta-analysis

V Chaudhary, S Kumari, B Pal - Biological Trace Element Research, 2023 - Springer
Visceral leishmaniasis (VL), a fatal disease prevalent in more than 70 countries, poses
significant health challenges, particularly in poor communities with limited access to …

A Novel Automated Framework for QSAR Modeling of Highly Imbalanced Leishmania High-Throughput Screening Data

O Casanova-Alvarez, A Morales-Helguera… - Journal of Chemical …, 2021 - ACS Publications
In silico prediction of antileishmanial activity using quantitative structure–activity relationship
(QSAR) models has been developed on limited and small datasets. Nowadays, the …

A Pluronic® F127-based polymeric micelle system containing an antileishmanial molecule is immunotherapeutic and effective in the treatment against Leishmania …

GSV Tavares, DVC Mendonça, CK Miyazaki… - Parasitology …, 2019 - Elsevier
Abstract Clioquinol (5-chloro-7-iodoquinolin-8-ol or ICHQ) was recently showed to presents
an in vitro effective antileishmanial action, causing changes in membrane permeability …

Molecular monitoring of treatment efficacy in human visceral leishmaniasis

S Roy, S Moulik, SJ Chaudhuri… - Transactions of The …, 2024 - academic.oup.com
Background Focused efforts of the visceral leishmaniasis elimination program have led to a
drastic decline in cases, and the present challenge is disease monitoring, which this study …

Visceral Leishmaniasis associated with Hemophagocytic lymphohistiocytosis

R Bolia, A Singh, M Maji, M Misra, IK Sharawat… - The Indian Journal of …, 2021 - Springer
To the Editor: An 18-mo-old toddler hailing from Nepal presented to us with persistent fever
of 4 mo duration, anemia and splenohepatomegaly. Laboratory studies demonstrated …

Antiprotozoal drugs

AT Black, DS McManus, OD Afolabi, SD Ray - Side effects of drugs annual, 2018 - Elsevier
This chapter provides a concise overview of adverse effects/events caused by drugs used as
anti-protozoal medications including drugs used for malaria, leishmaniasis, toxoplasmosis …

[HTML][HTML] Emerging Trends in Clinical Tropical Medicine Research

MK Huntington, JP Bryan, TD Moon… - The American Journal …, 2019 - ncbi.nlm.nih.gov
The American Society for Tropical Medicine and Hygiene recently inaugurated an award for
the best clinical research article published in the society's journal in the previous year. This …

[PDF][PDF] Perspective Piece

MK Huntington, JP Bryan, TD Moon… - Am. J. Trop. Med …, 2019 - academia.edu
The American Society for Tropical Medicine and Hygiene recently inaugurated an award for
the best clinical research article published in the society's journal in the previous year. This …

[引用][C] Efficacy and safety of treatment for Old World cutaneous leishmaniasis in pediatric patients: a case series

TB Cunha, T Bieber, I Reiter‐Owona… - JDDG: Journal der …, 2021 - Wiley Online Library
Efficacy and safety of treatment for Old World cutaneous leishmaniasis in pediatric patients: a
case series Page 1 Correspondence Clinical Letter 1067 © 2021 The Authors. Journal der …