Motor neuron (MN) diseases, including amyotrophic lateral sclerosis, progressive bulbar
palsy, primary lateral sclerosis and spinal muscular atrophy, cause progressive paralysis …

Mitochondria have multiple functions such as supplying energy, regulating the redox status,
and producing proteins encoded by an independent genome. They are closely related to the …

Understanding the retinogeniculate pathway in vitro can offer insights into its development
and potential for future therapeutic applications. This study presents a Polydimethylsiloxane …

Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations
in various genes with fundamental roles in the development and function of peripheral …

Cell culture devices, such as microwells and microfluidic chips, are designed to increase the
complexity of cell-based models while retaining control over culture conditions and have …

Technologies for axon guidance for in vitro disease models and bottom up investigations are
increasingly being used in neuroscience research. One of the most prevalent patterning …

The axon is a neuronal structure capable of processing, encoding, and transmitting
information. This assessment contrasts with a limiting, but deeply rooted, perspective where …

Axonal degeneration underlies neuromuscular disorders and neuropathies. Dysregulation
of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), in the peripheral …

Mitochondria are dynamic bioenergetic hubs that become compromised with age. In
neurons, declining mitochondrial axonal transport has been associated with reduced …

Eukaryotic cells undergo dramatic morphological changes during cell division, phagocytosis
and motility. Fundamental limits of cellular morphodynamics such as how fast or how much …