The role of the gut microbiome in colorectal cancer development and therapy response

L Sánchez-Alcoholado, B Ramos-Molina, A Otero… - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause
of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota …

Recent updates on mechanisms of resistance to 5-fluorouracil and reversal strategies in colon cancer treatment

S Azwar, HF Seow, M Abdullah, M Faisal Jabar… - Biology, 2021 - mdpi.com
Simple Summary Acquired resistance to chemotherapy by cancer cells is the predominant
factor in chemotherapy failure, which ultimately leads to disease progression and death …

Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer

M Volpato, MA Hull - Cancer and Metastasis Reviews, 2018 - Springer
The majority of evidence linking anti-colorectal cancer (CRC) activity with omega-3
polyunsaturated fatty acids (O3FAs) has focussed on decreased CRC risk (prevention) …

[HTML][HTML] Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value

Y Cui, HF Xu, MY Liu, YJ Xu, JC He… - World journal of …, 2019 - ncbi.nlm.nih.gov
BACKGROUND Exosomes contain proteins, lipids, and biological molecules such as DNA
and RNA. Nucleic acids in exosomes are a group of molecules that can act as biomarkers …

Omega-3 fatty acids, membrane remodeling and cancer prevention

NR Fuentes, E Kim, YY Fan, RS Chapkin - Molecular aspects of medicine, 2018 - Elsevier
Proteins are often credited as the macromolecule responsible for performing critical cellular
functions, however lipids have recently garnered more attention as our understanding of …

Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence of Hematopoietic Cell via Protecting Bone Marrow Stromal Cells from …

H Xiao, L Xiong, X Song, P Jin, L Chen, X Chen… - International journal of …, 2017 - mdpi.com
Myelosuppression is the most common complication of chemotherapy. Decline of self-
renewal capacity and stress-induced premature senescence (SIPS) of hematopoietic stem …

Fish oil and corn oil induced differential effect on beiging of visceral and subcutaneous white adipose tissue in high-fat-diet-induced obesity

P Sharma, N Agnihotri - The Journal of Nutritional Biochemistry, 2020 - Elsevier
Obesity is characterised by excessive accumulation of fat in white adipose tissue (WAT)
which is compartmentalised into two anatomically and functionally diverse depots-visceral …

n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation

F Picou, C Debeissat, J Bourgeais, N Gallay… - Pharmacological …, 2018 - Elsevier
Abstract Acute Myeloid Leukemia (AML) remains a therapeutic challenge and improvements
in chemotherapy are needed. n-3 polyunsaturated fatty acids (PUFAs), present in fish oil …

Restoring FAS expression via lipid-encapsulated FAS DNA nanoparticle delivery is sufficient to suppress colon tumor growth in vivo

AD Merting, DB Poschel, C Lu, JD Klement, D Yang… - Cancers, 2022 - mdpi.com
Simple Summary A key feature of human colorectal tumor is loss of FAS expression. FAS is
the death receptor for FASL of activated T cells. Loss of FAS expression therefore may …

Evaluation of Anticancer Activity of Novel and Tumor-Targeted Glutamine-Conjugated Organotin (IV) Compounds in Colorectal Cancer─ An In Vitro and In Vivo Study

S Sharma, V Kaur, P Duhan, R Singh… - Journal of Medicinal …, 2025 - ACS Publications
Over the years, numerous ligand-based organotin (IV) Schiff base compounds have shown
remarkable cytotoxicity and anticancer activities, but their clinical use is restricted by …