COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

[HTML][HTML] The effect of convalescent plasma therapy on mortality among patients with COVID-19: systematic review and meta-analysis

SA Klassen, JW Senefeld, PW Johnson, RE Carter… - Mayo Clinic …, 2021 - Elsevier
To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated
patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose …

COVID-19 convalescent plasma for the treatment of immunocompromised patients: a systematic review and meta-analysis

JW Senefeld, M Franchini, C Mengoli… - JAMA Network …, 2023 - jamanetwork.com
Importance Patients who are immunocompromised have increased risk for morbidity and
mortality associated with coronavirus disease 2019 (COVID-19) because they less …

[HTML][HTML] COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies

JD Goldman, PC Robinson, TS Uldrick… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. COVID-19 has highly
variable disease severity and a bimodal course characterized by acute respiratory viral …

Use of convalescent plasma in COVID‐19 patients with immunosuppression

JW Senefeld, SA Klassen, SK Ford, KA Senese… - …, 2021 - Wiley Online Library
In the absence of effective countermeasures, human convalescent plasma has been widely
used to treat severe acute respiratory syndrome coronavirus 2, the causative agent of novel …

[HTML][HTML] Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

J Wei, PC Matthews, N Stoesser, T Maddox… - Nature …, 2021 - nature.com
Understanding the trajectory, duration, and determinants of antibody responses after SARS-
CoV-2 infection can inform subsequent protection and risk of reinfection, however large …

Prolonged in‐hospital stay and higher mortality after Covid‐19 among patients with non‐Hodgkin lymphoma treated with B‐cell depleting immunotherapy

R Duléry, S Lamure, M Delord… - American journal of …, 2021 - Wiley Online Library
Prolonged Covid‐19 is an emerging issue for patients with lymphoma or immune deficiency.
We aimed to examine prolonged length of in‐hospital stay (LOS) due to Covid‐19 among …

SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

OV Stanevich, EI Alekseeva, M Sergeeva… - Nature …, 2023 - nature.com
Evolution of SARS-CoV-2 in immunocompromised hosts may result in novel variants with
changed properties. While escape from humoral immunity certainly contributes to intra-host …

Outcome of early treatment of SARS‐CoV‐2 infection in patients with haematological disorders

M Mikulska, D Testi, C Russo, E Balletto… - British Journal of …, 2023 - Wiley Online Library
Outcome of early treatment of COVID‐19 with antivirals or anti‐spike monoclonal antibodies
(MABs) in patients with haematological malignancies (HM) is unknown. A retrospective …

Incidence, clinical presentation, relapses and outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients treated with anti-CD20 …

J Calderón-Parra, E Múñez-Rubio… - Clinical Infectious …, 2022 - academic.oup.com
Background Our objective is to describe the presentation and complications, including
relapses, of coronavirus disease 2019 (COVID-19) in patients under anti-CD20 treatments …