Abstract c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however,
emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK …

Clonal alterations in hematopoietic cells occur during aging and are often associated with
the establishment of a subclinical inflammatory environment. Several age-related conditions …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues
from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling …

Epithelial repair relies on the activation of stress signaling pathways to coordinate tissue
repair. Their deregulation is implicated in chronic wound and cancer pathologies. Using TNF …

An important unanswered question in regenerative biology is to what extent regeneration is
accomplished by the reactivation of gene regulatory networks used during development …

The Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family.
It appears to be conserved in all animal species where it regulates important physiological …

While calcium signaling in excitable cells, such as muscle or neurons, is extensively
characterized, calcium signaling in epithelial tissues is little understood. Specifically, the …

The suppressor of cytokine signaling (SOCS) family of intracellular proteins has a vital role
in the regulation of the immune system and resolution of inflammatory cascades. SOCS1 …

Like tissues of many organisms, Drosophila imaginal discs lose the ability to regenerate as
they mature. This loss of regenerative capacity coincides with reduced damage-responsive …