The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Considerations for novel COVID-19 mucosal vaccine development

W Alturaiki - Vaccines, 2022 - mdpi.com
Mucosal surfaces are the first contact sites of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). Most SARS-CoV-2 vaccines induce specific IgG responses …

Blood DNA methylation and COVID-19 outcomes

J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …

Persistent blood DNA methylation changes one year after SARS-CoV-2 infection

J Balnis, A Madrid, KJ Hogan, LA Drake, A Adhikari… - Clinical …, 2022 - Springer
We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile.
Here, we hypothesized that some of these genes would persist differentially methylated after …

Protection by metformin against severe Covid-19: An in-depth mechanistic analysis

N Wiernsperger, A Al-Salameh, B Cariou… - Diabetes & …, 2022 - Elsevier
Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19
have reported a favourable association between metformin and Covid-19-related outcomes …

Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

A Budhraja, A Basu, A Gheware… - Disease Models & …, 2022 - journals.biologists.com
To elucidate the molecular mechanisms that manifest lung abnormalities during severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole …

Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study

J Balnis, A Madrid, LA Drake, R Vancavage, A Tiwari… - Ebiomedicine, 2024 - thelancet.com
Background DNA methylation integrates environmental signals with transcriptional
programs. COVID-19 infection induces changes in the host methylome. While post-acute …

[HTML][HTML] Interleukin-1β and interleukin-10 profiles and ratio in serum of COVID-19 patients and correlation with COVID-19 severity: a time series study

R Yudhawati, S Sakina, M Fitriah - International Journal of General …, 2022 - ncbi.nlm.nih.gov
Background Coronavirus disease-19 (COVID-19) can, in severe cases, lead to cytokine-
release syndrome owing to an excessive immune response. The release of different …

SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10

AMC Gomes, GB Farias, M Dias‐Silva… - European Journal of …, 2021 - Wiley Online Library
Accelerate lung repair in SARS‐CoV‐2 pneumonia is essential for pandemic handling.
Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and …

Peripheral blood omics and other multiplex-based systems in pulmonary and critical care medicine

J Balnis, EJM Lauria, R Yucel, HA Singer… - American Journal of …, 2023 - atsjournals.org
Over the last years, the use of peripheral blood–derived big datasets in combination with
machine learning technology has accelerated the understanding, prediction, and …