IL-7: comprehensive review
Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …
Type I cytokine receptors. It is produced by stromal cells and is required for development …
From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation
T Möröy, L Vassen, B Wilkes… - Blood, The Journal of …, 2015 - ashpublications.org
The DNA-binding zinc finger transcription factors Gfi1 and Gfi1b were discovered more than
20 years ago and are recognized today as major regulators of both early hematopoiesis and …
20 years ago and are recognized today as major regulators of both early hematopoiesis and …
Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation
M Minnich, H Tagoh, P Bönelt, E Axelsson… - Nature …, 2016 - nature.com
The transcription factor Blimp-1 is necessary for the generation of plasma cells. Here we
studied its functions in plasmablast differentiation by identifying regulated Blimp-1 target …
studied its functions in plasmablast differentiation by identifying regulated Blimp-1 target …
Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B–cell differentiation
I Ferreirós-Vidal, T Carroll, B Taylor… - Blood, The Journal …, 2013 - ashpublications.org
Ikaros family DNA-binding proteins are critical regulators of B-cell development. Because
the current knowledge of Ikaros targets in B-cell progenitors is limited, we have identified …
the current knowledge of Ikaros targets in B-cell progenitors is limited, we have identified …
The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression
K Miyazaki, M Miyazaki - Frontiers in immunology, 2021 - frontiersin.org
Cell type-specific gene expression is driven through the interplay between lineage-specific
transcription factors (TFs) and the chromatin architecture, such as topologically associating …
transcription factors (TFs) and the chromatin architecture, such as topologically associating …
RAG deficiencies: Recent advances in disease pathogenesis and novel therapeutic approaches
M Bosticardo, F Pala… - European journal of …, 2021 - Wiley Online Library
The RAG1 and RAG2 proteins initiate the process of V (D) J recombination and therefore
play an essential role in adaptive immunity. While null mutations in the RAG genes cause …
play an essential role in adaptive immunity. While null mutations in the RAG genes cause …
Multifaceted actions of GFI1 and GFI1B in hematopoietic stem cell self-renewal and lineage commitment
H Beauchemin, T Möröy - Frontiers in Genetics, 2020 - frontiersin.org
Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small
nuclear proteins that act as DNA binding transcriptional repressors. Both recognize the …
nuclear proteins that act as DNA binding transcriptional repressors. Both recognize the …
Role of GFI1 in epigenetic regulation of MDS and AML pathogenesis: mechanisms and therapeutic implications
T Möröy, C Khandanpour - Frontiers in Oncology, 2019 - frontiersin.org
Growth factor independence 1 (GFI1) is a DNA binding zinc finger protein, which can
mediate transcriptional repression mainly by recruiting histone-modifying enzymes to its …
mediate transcriptional repression mainly by recruiting histone-modifying enzymes to its …
Growth Factor Independence 1b (Gfi1b) Is Important for the Maturation of Erythroid Cells and the Regulation of Embryonic Globin Expression
L Vassen, H Beauchemin, W Lemsaddek, J Krongold… - PloS one, 2014 - journals.plos.org
Growth factor independence 1b (GFI1B) is a DNA binding repressor of transcription with vital
functions in hematopoiesis. Gfi1b-null embryos die at midgestation very likely due to defects …
functions in hematopoiesis. Gfi1b-null embryos die at midgestation very likely due to defects …
Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+ CD8+ thymocytes
Expression of Rag1 and Rag2 is tightly regulated in developing T cells to mediate TCR gene
assembly. Here we have investigated the molecular mechanisms governing the assembly …
assembly. Here we have investigated the molecular mechanisms governing the assembly …