Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The epidermis is a stratified squamous epithelium forming the barrier that excludes harmful
microbes and retains body fluids. To perform these functions, proliferative basal cells in the …

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue
architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the …

Mitotic spindle positioning by cortical pulling forces defines the cell division axis and
location, which is critical for proper cell division and development. Although recent work has …

Stem and progenitor cells use asymmetric cell divisions to balance proliferation and
differentiation. Evidence from invertebrates shows that this process is regulated by proteins …

Abstract Development of a multicellular organism from a fertilized egg depends on a precise
balance between symmetric cell divisions to expand the pool of similar cells, and …

During mammalian development, neuroepithelial cells function as mitotic progenitors, which
self-renew and generate neurons. Although spindle orientation is important for such …