Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …

Accumulating evidence indicates an important pathophysiological role of brain inflammation
in epilepsy. In this review, we will provide an update of specific inflammatory pathways that …

Epilepsy, a common multifactorial neurological disease, affects about 69 million people
worldwide constituting nearly 1% of the world population. Despite decades of extensive …

The possibility that inflammatory processes in the brain contribute to the etiopathogenesis of
seizures and the establishment of a chronic epileptic focus is increasingly recognized as a …

CNS injuries such as trauma, stroke, viral infection, febrile seizures, status epilepticus
occurring either in infancy or during a lifetime are considered common risk factors for …

Increasing evidence supports a pathogenic role of unabated neuroinflammation in various
central nervous system (CNS) diseases, including epilepsy. Neuroinflammation is not a …

Existing therapies for epilepsy are primarily symptomatic and target mechanisms of neuronal
transmission in order to restore the excitatory/inhibitory imbalance in the brain after seizures …

Cyclooxygenase-2 (COX-2), a source of inflammatory mediators and a multifunctional
neuronal modulator, is rapidly induced in select populations of cortical neurons after status …

The enzyme cyclooxygenase-2 (COX-2), which catalyzes the production of pro-inflammatory
prostaglandins, is induced in the brain after various insults, thus contributing to brain …