Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

The chromosomal loci known as centromeres (CEN) mediate the equal distribution of the
duplicated genome between both daughter cells. Specifically, centromeres recruit a protein …

DNA double-strand breaks (DSBs) occur in our cells in the context of chromatin. This type of
lesion is toxic, entirely preventing genome continuity and causing cell death or terminal …

Cancer and obesity are the two major epidemics of the 21st century. Pancreatic ductal
adenocarcinoma (PDAC) is one of the leading causes of death, with a five-year overall …

Tandemly repeated satellite DNAs are major components of centromeres and
pericentromeric heterochromatin which are crucial chromosomal elements responsible for …

Research on extracellular vesicles (EVs) has been expanded, especially in the field of
cancer. The cargoes in EVs, especially those in small EVs such as exosomes include …

Satellite DNAs are tandemly repeated sequences organized in large clusters within (peri)
centromeric and/or subtelomeric heterochromatin. However, in many species, satellite DNAs …

Objective To assess the genetic and epigenetic effects promoted by Bisphenol A (BPA)
exposure in adolescent males from the Spanish INMA-Granada birth cohort, and in human …

Centromere genomics remain poorly characterized in cancer, due to technologic limitations
in sequencing and bioinformatics methodologies that make high-resolution delineation of …

Extracellular vesicles (EVs) are intercellular communication agents that transfer microRNAs
(miRNAs), other non‐coding RNAs (ncRNAs), messenger RNAs (mRNAs), proteins, lipids …