A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a
genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 …

Although genome-wide association studies are widely used to mine genes for quantitative
traits, the effects to be estimated are confounded, and the methodologies for detecting …

The state-of-the-art knowledge of ferroelectric and ferroelastic group-IV monochalcogenide
monolayers is surveyed. These semiconductors feature remarkable structural and …

Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …

Background Parkinson's disease (PD) is a neurodegenerative disease with an often
complex component identifiable by genome‐wide association studies. The most recent large …

One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …