A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous
solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous …

Purpose: The blood–brain barrier (BBB) presents both a physical and electrostatic barrier to
limit brain permeation of therapeutics. Previous work has demonstrated that nanoparticles …

Liposomes are clinically used drug carriers designed to improve the delivery of drugs to
specific tissues while minimising systemic distribution. However, liposomes are unable to …

In recent years, a new generation of drugs has entered the pharmaceutical market. Some
are more potent, but some are also more toxic and thus, therapeutical efficacy may be …

The intracellular fate of particulate drug delivery systems is determined by the initial mode of
internalization and the subsequent intracellular trafficking. Besides clathrin-mediated …

Accumulating evidence supports the association of somatic mutations with tumor occurrence
and development. We aimed to identify somatic mutations with important implications in …

The aim of this study was to investigate the influence of the nanocarrier surface charge on
brain delivery of a model hydrophilic drug via the nasal route. Anionic and cationic …

There is significant current interest in identifying new combination therapies that synergize to
treat disease, and it is becoming increasingly clear that the temporal resolution of their …

We highlight the importance of the low-density lipoprotein (LDL) receptor family and its
pharmaceutical implications in the field of drug delivery. The members of the LDL receptor …