The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …

Objective: This study aims to clarify the role of surfactant and drug molecular structures on
drug solubility in micellar surfactant solutions. Significance:(1) Rationale for surfactant …

Despite countless advances in recent decades across various in vitro, in vivo and in silico
tools, anticipation of whether a drug will show a human food effect (FE) remains challenging …

The purpose of this study was to explore gastrointestinal dissolution, supersaturation and
precipitation of the weakly basic drug posaconazole in humans, and to assess the impact of …

Pharmaceutical research needs predictive in vitro tools for API bioavailability in humans. We
evaluated two dynamic in vitro gastrointestinal models: TIM-1 and tiny-TIM. Four low-soluble …

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral
administration, including GI transfer, motility, pH and GI fluid volume and composition. An in …

Before being absorbed in the small intestine and/or colon, orally administered drugs
inevitably need to pass through the stomach. Hence, it seems reasonable that the residence …

Mechanistic modeling of in vitro data generated from metabolic enzyme systems (viz., liver
microsomes, hepatocytes, rCYP enzymes, etc.) facilitates in vitro–in vivo extrapolation …

The dissolution, intestinal absorption and presystemic metabolism of a drug depend on its
physicochemical characteristics but also on numerous physiological (eg gastrointestinal pH …