[HTML][HTML] Advances and challenges in the treatment of lung cancer

Y Li, B Yan, S He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer accounts for a relatively high proportion of malignant tumors. As the most
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Recent progress of biosensors for the detection of lung cancer markers

S Chen, M Li, T Weng, D Wang, J Geng - Journal of Materials …, 2023 - pubs.rsc.org
Lung cancer is one of the most common cancers worldwide and the leading cause of death.
Early screening of lung cancer is exceptionally essential for later treatment. Abnormal lung …

[HTML][HTML] PIK3CA mutation as an acquired resistance driver to EGFR-TKIs in non-small cell lung cancer: Clinical challenges and opportunities

X Liu, W Mei, P Zhang, C Zeng - Pharmacological Research, 2024 - Elsevier
Epithelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have significantly
enhanced the treatment outcomes in non-small cell lung cancer (NSCLC) patients harboring …

[HTML][HTML] The cell line models to study tyrosine kinase inhibitors in non-small cell lung cancer with mutations in the epidermal growth factor receptor: A scoping review

A Belloni, A Pugnaloni, MR Rippo, S Di Valerio… - Critical Reviews in …, 2024 - Elsevier
Abstract Non-Small Cell Lung Cancer (NSCLC) represents∼ 85% of all lung cancers and∼
15–20% of them are characterized by mutations affecting the Epidermal Growth Factor …

Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: prevailing insights on molecular pathways, diagnosis, and nanomedicine …

B Bhattacharjee, AF Syeda, D Rynjah… - Frontiers in …, 2023 - frontiersin.org
Head and neck squamous cell carcinoma is a disease that most commonly produce tumours
from the lining of the epithelial cells of the lips, larynx, nasopharynx, mouth, or oro-pharynx. It …

Prmt-1 and P120-catenin as emt mediators in osimertinib resistance in nsclc

KS Racherla, K Dovalovsky, M Patel, E Harper… - Cancers, 2023 - mdpi.com
Simple Summary Non-small-cell lung cancer (NSCLC) patients become resistant to targeted
therapies such as tyrosine kinase inhibitors (TKIs) through mutations in the EGFR gene and …

Tumor microenvironmental cytokines drive NSCLC cell aggressiveness and drug-resistance via YAP-mediated autophagy

P Matarrese, R Vona, B Ascione, C Cittadini, A Tocci… - Cells, 2023 - mdpi.com
Dynamic reciprocity between cellular components of the tumor microenvironment and tumor
cells occurs primarily through the interaction of soluble signals, ie, cytokines produced by …

Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma

M Onda, A Ota, K Ito, T Ono, S Karnan, M Kato… - Cancer …, 2023 - Wiley Online Library
Background Epidermal growth factor receptor (EGFR) is frequently overexpressed in oral
squamous cell carcinoma (OSCC), and EGFR‐targeting therapeutics have been widely …

Recent development of VEGFR small molecule inhibitors as anticancer agents: A patent review (2021–2023)

J Zeng, Q Deng, Z Chen, S Yan, Q Dong, Y Zhang… - Bioorganic …, 2024 - Elsevier
VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that
promotes angiogenesis and vascular permeability. It plays a significant role in processes …