IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic
target. Here we report the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 …

Myeloid cells are recruited to damaged tissues where they can resolve infections and tumor
growth or stimulate wound healing and tumor progression. Recruitment of these cells is …

Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent
player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is …

Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber
maintenance, repair and remodeling. Our knowledge of the role of satellite cells in muscle …

Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

The MYC proto-oncogene is a gene product that coordinates the transcriptional regulation of
a multitude of genes that are essential to cellular programs required for normal as well as …