This review covers recent developments in the area of particle engineering via spray drying.
The last decade has seen a shift from empirical formulation efforts to an engineering …

Remarkably, with the exception of anaesthetic gases, the ancient human practice of inhaling
substances into the lungs for systemic effect has only just begun to be adopted by modern …

In the 50 years following the introduction of the first dry powder inhaler to the market, several
developments have occurred. Multiple-unit dose and multi-dose devices have been …

Because of limitations associated with the conventional treatment of various chronic
diseases a growing attention has been given to the development of targeted drug delivery …

Many patients with advanced type 2 diabetes mellitus (T2DM) and all patients with T1DM
require insulin to keep blood glucose levels in the target range. The most common route of …

The advent of nanotechnology has reignited interest in the lungs as a major route of drug
delivery for both systemic and local treatments. The large surface area of the lungs and the …

Although there is a modest body of literature on the absorption of inhaled pharmaceuticals
by normal lungs and some limited information from diseased lungs, there is still a surprising …

Background: Although various injected peptide and protein therapeutics have been
developed successfully over the past 25 years, several pharmacokinetic and immunological …

Pulmonary delivery of lipid-based nanotherapeutics by inhalation presents an
advantageous alternative to oral and intravenous routes of administration that avoids …

Development of a product for pulmonary delivery of insulin presented significant technology
challenges for this first-in-class pharmaceutical product. These included developing (a) a …