Carboxylic acids as adaptive functional groups in metallaphotoredox catalysis

SB Beil, TQ Chen, NE Intermaggio… - Accounts of chemical …, 2022 - ACS Publications
Conspectus The development of palladium-catalyzed cross-coupling methods for the
activation of C (sp2)–Br bonds facilitated access to arene-rich molecules, enabling a …

Enantioselective Transformations in the Synthesis of Therapeutic Agents

H Yang, H Yu, IA Stolarzewicz, W Tang - Chemical Reviews, 2023 - ACS Publications
The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …

Metabolic and pharmaceutical aspects of fluorinated compounds

BM Johnson, YZ Shu, X Zhuo… - Journal of medicinal …, 2020 - ACS Publications
The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …

Critical enzyme reactions in aromatic catabolism for microbial lignin conversion

E Erickson, A Bleem, E Kuatsjah, AZ Werner… - Nature Catalysis, 2022 - nature.com
The application of microbes to valorize aromatic compounds derived from the abundant
plant biopolymer lignin is a rapidly developing area of research that may ultimately enable …

Microbial lignin valorization through depolymerization to aromatics conversion

F Li, Y Zhao, L Xue, F Ma, SY Dai, S Xie - Trends in biotechnology, 2022 - cell.com
Lignin is the most abundant source of renewable aromatic biopolymers and its valorization
presents significant value for biorefinery sustainability, which promotes the utilization of …

A General Iron‐Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids

LM Denkler, M Aladahalli Shekar, TSJ Ngan… - Angewandte …, 2024 - Wiley Online Library
We report an iron‐catalyzed decarboxylative C (sp3)− O bond‐forming reaction under mild,
base‐free conditions with visible light irradiation. The transformation uses readily available …

Thiamin function, metabolism, uptake, and transport

S Manzetti, J Zhang, D van der Spoel - Biochemistry, 2014 - ACS Publications
Vitamins are crucial components in the diet of animals and many other living organisms.
One of these essential nutrients, thiamin, is known to be involved in several cell functions …

Vitamin B6-Based Biomimetic Asymmetric Catalysis

X Xiao, B Zhao - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus One of the fundamental goals of chemists is to develop highly efficient methods
for producing optically active compounds, given their wide range of applications in …

Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

F Steffen-Munsberg, C Vickers, H Kohls, H Land… - Biotechnology …, 2015 - Elsevier
In this review we analyse structure/sequence–function relationships for the superfamily of
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …

New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition

KAP Payne, MD White, K Fisher, B Khara, SS Bailey… - Nature, 2015 - nature.com
The bacterial ubiD and ubiX or the homologous fungal fdc1 and pad1 genes have been
implicated in the non-oxidative reversible decarboxylation of aromatic substrates, and play a …