Schistosomiasis continues to be a significant cause of parasitic morbidity and mortality
worldwide. This review considers the basic features of the pathology and clinical outcomes …

Abstract Before Robert Koch's work in the late nineteenth century, diseases such as
tuberculosis and leprosy were widely believed to be inherited disorders. Heritability of …

The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in
China has invoked considerable global concern. The TGD will result in changes in the water …

Human genetic variation is an important determinant of the outcome of infection with
Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to …

A genetic basis for interindividual variation in susceptibility to human infectious diseases has
been indicated by twin, adoptee, pedigree, and candidate gene studies. This has led to the …

Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after
severe injury caused by autoimmune reactions, mechanical stress or infections. The …

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India,
where about half of the world's estimated 800,000 cases occur 1. A role for the genetics of …

Infectious diseases represent a major health problem worldwide, both in terms of morbidity
and mortality. A complex combination of environmental, pathogen and host genetic factors …

Allergic diseases are on the increase globally in parallel with a decrease in parasitic
infection. The inverse association between parasitic infections and allergy at an ecological …

Lethal disease in Schistosoma mansoni infections is mostly due to portal hypertension
caused by hepatic periportal fibrosis. To evaluate the factors that may determine severe …