Cross-species virus transmission and the emergence of new epidemic diseases
CR Parrish, EC Holmes, DM Morens… - Microbiology and …, 2008 - Am Soc Microbiol
Host range is a viral property reflecting natural hosts that are infected either as part of a
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts …
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts …
Tripartite-motif proteins and innate immune regulation
FW McNab, R Rajsbaum, JP Stoye… - Current opinion in …, 2011 - Elsevier
The tripartite motif containing (TRIM) proteins are a family of proteins that have been
implicated in many biological processes including cell differentiation, apoptosis …
implicated in many biological processes including cell differentiation, apoptosis …
The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer
JG Sanchez, K Okreglicka… - Proceedings of the …, 2014 - National Acad Sciences
Tripartite motif (TRIM) proteins make up a large family of coiled-coil-containing RING E3
ligases that function in many cellular processes, particularly innate antiviral response …
ligases that function in many cellular processes, particularly innate antiviral response …
TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation
LM Napolitano, G Meroni - IUBMB life, 2012 - Wiley Online Library
The TRIM family is composed of multidomain ubiquitin E3 ligases characterized by the
presence of the N‐terminal tripartite motif (RING, B‐boxes, and coiled coil). TRIM proteins …
presence of the N‐terminal tripartite motif (RING, B‐boxes, and coiled coil). TRIM proteins …
A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish
Background A large multigene family of NOD-like receptor (NLR) molecules have been
described in mammals and implicated in immunity and apoptosis. Little information …
described in mammals and implicated in immunity and apoptosis. Little information …
The control of viral infection by tripartite motif proteins and cyclophilin A
GJ Towers - Retrovirology, 2007 - Springer
The control of retroviral infection by antiviral factors referred to as restriction factors has
become an exciting area in infectious disease research. TRIM5α has emerged as an …
become an exciting area in infectious disease research. TRIM5α has emerged as an …
Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals
TRIM5α provides a cytoplasmic block to retroviral infection, and orthologs encoded by some
primates are active against HIV. Here, we present an evolutionary comparison of the TRIM5 …
primates are active against HIV. Here, we present an evolutionary comparison of the TRIM5 …
A B-box 2 surface patch important for TRIM5α self-association, capsid binding avidity, and retrovirus restriction
F Diaz-Griffero, X Qin, F Hayashi, T Kigawa… - Journal of …, 2009 - Am Soc Microbiol
ABSTRACT TRIM5α is a tripartite motif (TRIM) protein that consists of RING, B-box 2, coiled-
coil, and B30. 2 (SPRY) domains. The TRIM5αrh protein from rhesus monkeys recognizes …
coil, and B30. 2 (SPRY) domains. The TRIM5αrh protein from rhesus monkeys recognizes …
Type I interferon‐dependent and‐independent expression of tripartite motif proteins in immune cells
R Rajsbaum, JP Stoye, A O'Garra - European journal of …, 2008 - Wiley Online Library
The tripartite motif (TRIM) proteins are important in a variety of cellular functions additional to
anti‐viral activity. We systematically analysed mRNA expression of representative TRIM …
anti‐viral activity. We systematically analysed mRNA expression of representative TRIM …