The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …

eIF2 plays a central role in the maintenance of what is generally considered a rate-limiting
step in mRNA translation. In this step, eIF2 binds GTP and Met-tRNAi and transfers Met …

Extracts of Tripterygium wilfordii hook. f.(leigong teng, Thundergod vine) are effective in
traditional Chinese medicine for treatment of immune inflammatory diseases including …

Summary p53, master transcriptional regulator of the genotoxic stress response, controls cell-
cycle arrest and apoptosis following DNA damage. Here, we identify a p53-induced lncRNA …

PG490 (triptolide) is a diterpene triepoxide with potent immunosuppressive and
antiinflammatory properties. PG490 inhibits interleukin (IL)-2 expression by normal human …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Mutations
in the Fused in Sarcoma/Translocated in Liposarcoma (FUS/TLS) gene cause a subset of …

Highly structured and double-stranded (ds) RNAs are adaptable and potent biochemical
entities. They interact with dsRNA-binding proteins (RBPs), the great majority of which …

Recently, we identified proteins that co‐purify with the human spliceosome using mass
spectrometry. One of the identified proteins, CDC5L, corresponds to the human homologue …

DNA double-strand breaks (DSBs) are a highly mutagenic and potentially lethal damage
that occurs in all organisms. Mammalian cells repair DSBs by homologous recombination …

Arginine methylation is a common post-translation modification found in many proteins.
Protein-arginine methyltransferase I (PRMT1) contributes> 90% of type I protein-arginine …