Highlights•Structural LTP produces opposite effects at synapses on immature versus adult
dendrites.•Local subcellular compartments mediate synaptogenesis at P15 and synapse …

The ability of neurons to communicate and store information depends on the activity of
synapses which can be located on small protrusions (dendritic spines) or directly on the …

In hippocampal pyramidal cells, a small subset of dendritic spines contain endoplasmic
reticulum (ER). In large spines, ER frequently forms a spine apparatus, while smaller spines …

Homeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength
to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on …

A defining feature of the brain is the ability of its synaptic contacts to adapt structurally and
functionally in an experience-dependent manner. In the human cortex, however, direct …

The spine apparatus is a specialized compartment of the neuronal smooth endoplasmic
reticulum (ER) located in a subset of dendritic spines. It consists of stacks of ER cisterns that …

Excitatory synapses of principal hippocampal neurons are frequently located on dendritic
spines. The dynamic strengthening or weakening of individual inputs results in structural …

The physiological role of the amyloid-precursor protein (APP) is insufficiently understood.
Recent work has implicated APP in the regulation of synaptic plasticity. Substantial evidence …

Developing neurons form synapses at a high rate. Synaptic transmission is very energy-
demanding and likely requires ATP production by mitochondria nearby. Mitochondria might …

Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of
developing Alzheimer's disease (AD). However, global cholesterol-lowering therapies have …