CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …

The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …

Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …