Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …

The ubiquitin proteasome system maintains protein homeostasis by regulating the
breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The …

Protein expression and turnover are controlled through a complex interplay of
transcriptional, post-transcriptional and post-translational mechanisms to enable spatial and …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD
have an expanded NH2-terminal polyglutamine region in huntingtin. An NH2-terminal …

Copper is found in all living organisms and is a crucial trace element in redox chemistry,
growth and development. It is important for the function of several enzymes and proteins …

▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …

▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein
modification by the polypeptide ubiquitin. These include key transitions in the cell cycle …

Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

Three archaeological sites at Katanda on the Upper Semliki River in the Western Rift Valley
of Zaire have provided evidence for a well-developed bone industry in a Middle Stone Age …