Role of mitochondrial cytochrome P450 2E1 in healthy and diseased liver
J Massart, K Begriche, JH Hartman, B Fromenty - Cells, 2022 - mdpi.com
Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and
different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing …
different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing …
The multifarious link between cytochrome P450s and cancer
AM Alzahrani, P Rajendran - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an
important role in the metabolism of endogenous as well as exogenous substances …
important role in the metabolism of endogenous as well as exogenous substances …
Unlocking the secrets: Volatile Organic Compounds (VOCs) and their devastating effects on lung cancer
Lung cancer (LCs) is still a serious health problem globally, with many incidences attributed
to environmental triggers such as Volatile Organic Compounds (VOCs). VOCs are a broad …
to environmental triggers such as Volatile Organic Compounds (VOCs). VOCs are a broad …
Increased levels of urine volatile organic compounds are associated with diabetes risk and impaired glucose homeostasis
X Duan, Z Chen, C Xia, R Zhong, L Liu… - The Journal of Clinical …, 2024 - academic.oup.com
Abstract Context Volatile organic compounds (VOCs) are pervasive environmental
pollutants that have been linked to various adverse health effects. However, the effect of …
pollutants that have been linked to various adverse health effects. However, the effect of …
Thermoplastic segmented polyhydroxyurethane: Biobased segments can lead to broad-temperature-range damping character in the absence of inter-segment …
Y Chen, JM Torkelson - European Polymer Journal, 2024 - Elsevier
We synthesized segmented thermoplastic polyhydroxyurethanes (PHUs) by reacting one of
three biowaste-derivable cyclic carbonates, NC-514-CC, Cyclo-CC or 1, 3-BD-CC, with an …
three biowaste-derivable cyclic carbonates, NC-514-CC, Cyclo-CC or 1, 3-BD-CC, with an …
New rodent population models may inform human health risk assessment and identification of genetic susceptibility to environmental exposures
AH Harrill, KA McAllister - Environmental health perspectives, 2017 - ehp.niehs.nih.gov
Background: This paper provides an introduction for environmental health scientists to
emerging population-based rodent resources. Mouse reference populations provide an …
emerging population-based rodent resources. Mouse reference populations provide an …
Whole genome sequencing and progress toward full inbreeding of the mouse collaborative cross population
Two key features of recombinant inbred panels are well-characterized genomes and
reproducibility. Here we report on the sequenced genomes of six additional Collaborative …
reproducibility. Here we report on the sequenced genomes of six additional Collaborative …
Associations of urinary 1, 3-butadiene metabolite with glucose homeostasis, prediabetes, and diabetes in the US general population: role of alkaline phosphatase
R Liang, X Feng, D Shi, L Yu, M Yang, M Zhou… - Environmental …, 2023 - Elsevier
Abstract The chemical–1, 3-butadiene (BD) is a volatile organic compound ubiquitous in the
environment. However, the relationships and underlying mechanisms between BD exposure …
environment. However, the relationships and underlying mechanisms between BD exposure …
Toxicological implications of mitochondrial localization of CYP2E1
Abstract Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants,
drugs, and other small molecules, often resulting in bioactivation to reactive metabolites …
drugs, and other small molecules, often resulting in bioactivation to reactive metabolites …
Exposure to volatile organic compounds and mortality in US adults: A population-based prospective cohort study
X Feng, F Qiu, L Zheng, Y Zhang, Y Wang… - Science of The Total …, 2024 - Elsevier
Volatile organic compounds (VOCs) are ubiquitous in both indoor and outdoor
environments. Evidence on the associations of individual and joint VOC exposure with all …
environments. Evidence on the associations of individual and joint VOC exposure with all …