For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …

A major unanswered question in the dementia field is whether cognitively unimpaired
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …

Disease staging, whereby the spatial extent and load of brain pathology are used to
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …

Staging the severity of Alzheimer's disease pathology using biomarkers is useful for
therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face …

In early Alzheimer's disease (AD) β-amyloid (Aβ) deposits throughout association cortex and
tau appears in the entorhinal cortex (EC). Why these initially appear in disparate locations is …

Rates of tau accumulation in cognitively unimpaired older adults are subtle, with magnitude
and spatial patterns varying in recent reports. Regional accumulation also likely varies in the …

OBJECTIVE: Recent evidence shows that indicators testing conventional olfactory function
have a high degree of similarity to cognitive function tests and the potential to diagnose early …

Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen
during the progression of Alzheimer's disease (AD). Although it is not well-established what …

Background To better assist with the design of future clinical trials for Alzheimer's disease
(AD) and aid in our understanding of the disease's symptomatology, it is essential to clarify …

Purpose Left-right asymmetry, an important feature of brain development, has been
implicated in neurodegenerative diseases, although it's less discussed in typical Alzheimer's …