The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

Brain vascular calcification is a prevalent age-related condition often accompanying
neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel …

Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …

Pericytes, the mural cells of blood microvessels, regulate microvascular development and
function and have been implicated in many brain diseases. However, due to a paucity of …

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Neurodegenerative and cerebrovascular diseases cause considerable human suffering,
and therapy options for these two disease categories are limited or non‐existing. It is an …

Pericytes regulate the development of organ-specific characteristics of the brain vasculature
such as the blood–brain barrier (BBB) and astrocytic end-feet. Whether pericytes are …

Primary familial brain calcification (PFBC), also known as Fahr's disease, is a rare inherited
disorder characterized by bilateral calcification in the basal ganglia according to …