A cross‐sectional study of ageing at the mouse neuromuscular junction and effects of an experimental therapeutic approach for dynapenia
Despite prior efforts to understand and target dynapenia (age‐induced loss of muscle
strength), this condition remains a major challenge that reduces the quality of life in the aged …
strength), this condition remains a major challenge that reduces the quality of life in the aged …
[HTML][HTML] The effect of GV-58, a calcium channel modifier, on synaptic transmission at the larval Drosophila and crayfish neuromuscular junctions
J Schwamburger, K Brock… - microPublication Biology, 2024 - pmc.ncbi.nlm.nih.gov
GV-58 is known to increase the opening time of the mammalian P-type calcium channel in
presynaptic motor nerve terminals. GV-58 is suggested as a therapeutic agent for …
presynaptic motor nerve terminals. GV-58 is suggested as a therapeutic agent for …
Nifedipine ameliorates cellular differentiation defects of Smn-deficient motor neurons and enhances neuromuscular transmission in SMA mice
R Tejero, M Alsakkal, L Hennlein… - International Journal of …, 2023 - mdpi.com
In spinal muscular atrophy (SMA), mutations in or loss of the Survival Motor Neuron 1
(SMN1) gene reduce full-length SMN protein levels, which leads to the degeneration of a …
(SMN1) gene reduce full-length SMN protein levels, which leads to the degeneration of a …