Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose
individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 …

This account of the highlights of the eighth St Gallen (Switzerland) meeting in 2003
emphasizes new information that has emerged during the 2 years since the seventh meeting …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

BRCA1-BARD1 constitutes a heterodimeric RING finger complex associated through its N-
terminal regions. Here we demonstrate that the BRCA1-BARD1 heterodimeric RING finger …

DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce
mutations, chromosomal rearrangements and cell death. Inducers of ICLs are important …

DEVELOPMENT OF treatment guidelines for early breast cancer requires comprehensive
analysis of the results of randomized clinical trials and the interpretation of their biologic …

Introduction: The literature of orphan drugs and rare diseases between 2000 and 2014 is
reviewed. The overall structure of its intellectual landscape is characterized in terms of …

We review the genes and proteins related to the homologous recombinational repair (HRR)
pathway that are implicated in cancer through either genetic disorders that predispose to …

Senescence may function as a two-edged sword that brings unexpected consequences to
organisms. Here we provide evidence to support this theory by showing that the absence of …

Background: Germline mutations in BRCA1 and BRCA2 are responsible for 5%–10% of
epithelial ovarian cancers, but the molecular pathways affected by these mutations are …