The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …

Cytotoxic T lymphocyte (CTL) responses against tumors are maintained by stem-like
memory cells that self-renew but also give rise to effector-like cells. The latter gradually lose …

Resident memory T cells (T RM cells) are an important first-line defense against respiratory
pathogens, but the unique contributions of lung T RM cell populations to protective immunity …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated
effector T cells, but the mechanisms that control the extent of TRM differentiation within …

The liver provides a tolerogenic immune niche exploited by several highly prevalent
pathogens as well as by primary and metastatic tumors. We have sampled healthy and …

Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have
shown promise; however, clinical responses to the immunotherapeutic agents currently …

Abstract An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ
Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks …