Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …

Conspectus Biomembranes are ubiquitous lipid structures that delimit the cell surface and
organelles and operate as platforms for a multitude of biomolecular processes. The …

Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system
for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with …

The ultimate microscope, directed at a cell, would reveal the dynamics of all the cell's
components with atomic resolution. In contrast to their real-world counterparts …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Dietary lipids impact development, homeostasis, and disease, but links between specific
dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of …

Oxidized phospholipids that result from tissue injury operate as immunomodulatory signals
that, depending on the context, lead to proinflammatory or anti-inflammatory responses. In …

Maintenance of lipid asymmetry across the two leaflets of the plasma membrane (PM)
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …