Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Abstract N6-methyladenosine (m6A) on chromosome-associated regulatory RNAs
(carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and …

During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …

Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of
transposable elements (TEs), which they repress with their cofactor KAP1 through histone …

In mammalian cells, multiple cellular processes, including gene silencing, cell growth and
differentiation, pluripotency, neoplastic transformation, apoptosis, DNA repair, and …

Retrotransposons encompass half of the human genome and contribute to the formation of
heterochromatin, which provides nuclear structure and regulates gene expression. Here, we …

Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular
biology has been extensively studied resulting in identification of a complex nature of …

Background Rewriting of the epigenome has risen as a promising alternative to gene editing
for precision medicine. In nature, epigenetic silencing can result in complete attenuation of …