Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

Alzheimer's disease (AD) is considered to be the most common cause of dementia and is an
incurable, progressive neurodegenerative disorder. Current treatment of the disease …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Cognitive dysfunction is one of the most typical characteristics in various neurodegenerative
diseases such as Alzheimer's disease and Parkinson's disease (advanced stage). Although …

Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …

Alzheimer's disease (AD) is one of the most frequent causes of death and disability
worldwide and has a significant clinical and socioeconomic impact. In the search for novel …

Cognitive deficits in schizophrenia severely compromise quality of life and are poorly
controlled by current antipsychotics. While 5‐HT6 receptor blockade holds special promise …

Alzheimer's disease (AD) is the most common cause of dementia in elderly people. Because
of the lack of effective treatments for this illness, research focused on identifying compounds …

Since its discovery in 1993 and subsequent development of selective antagonists, a growing
number of studies support the use of serotonin 5-HT6 receptor antagonism as a promising …

Mounting evidence accumulated over the past few years indicates that the neurotransmitter
serotonin plays a significant role in cognition. As a drug target, serotonin receptors have …