Naturally occurring mutations in G protein-coupled receptors associated with obesity and type 2 diabetes mellitus
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors involved
in the regulation of almost all known physiological processes. Dysfunctions of GPCR …
in the regulation of almost all known physiological processes. Dysfunctions of GPCR …
Ghrelin receptor signaling in health and disease: a biased view
As allosteric complexes, G-protein-coupled receptors (GPCRs) respond to extracellular
stimuli and pleiotropically couple to intracellular transducers to elicit signaling pathway …
stimuli and pleiotropically couple to intracellular transducers to elicit signaling pathway …
[HTML][HTML] LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue
Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
[HTML][HTML] A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes
Background The hormone ghrelin stimulates food intake, promotes adiposity, increases
body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels …
body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels …
The intriguing ligand-dependent and ligand-independent actions of the growth hormone secretagogue receptor on reward-related behaviors
The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …
The ups and downs of growth hormone secretagogue receptor signaling
The growth hormone secretagogue receptor (GHSR) has emerged as one of the most
fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly …
fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly …
[HTML][HTML] Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions
D Gupta, AM Patterson, S Osborne-Lawrence… - Molecular …, 2021 - Elsevier
Objective Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon
binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor) …
binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor) …
A new understanding of GHSR1a——independent of ghrelin activation
X Xiao, M Bi, Q Jiao, X Chen, X Du, H Jiang - Ageing Research Reviews, 2020 - Elsevier
Growth hormone secretagogue receptor 1a (GHSR1a), a member of the G protein-coupled
receptor (GPCR) family, is a functional receptor of ghrelin. The expression levels and …
receptor (GPCR) family, is a functional receptor of ghrelin. The expression levels and …
Contribution of ghrelin to the pathogenesis of growth hormone deficiency
A Lewiński, M Karbownik-Lewińska… - International Journal of …, 2021 - mdpi.com
In this review we described the interactions between ghrelin and the growth hormone (GH)-
insulin-like growth factor 1 (IGF-1) axis in children and adults with growth hormone …
insulin-like growth factor 1 (IGF-1) axis in children and adults with growth hormone …
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation
The biological signals of hunger, satiety, and memory are interconnected. The role of the
hormone ghrelin in regulating feeding and memory makes ghrelin receptors attractive …
hormone ghrelin in regulating feeding and memory makes ghrelin receptors attractive …