The skin is the biggest organ of human body which acts as a protective barrier against
deleterious agents. When this barrier is damaged, the organism promotes the healing …

Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

The uterine lining (endometrium) regenerates repeatedly over the life span as part of its
normal physiology. Substantial portions of the endometrium are shed during childbirth …

Cancer treatments are increasingly effective, but can result in iatrogenic premature ovarian
insufficiency. Ovarian tissue cryopreservation is the only option available to preserve fertility …

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway regulates
cell proliferation, differentiation, and migration, along with angiogenesis and metabolism …

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) that leads to
progressive bone marrow (BM) fibrosis. Although the cellular mutations involved in the …

Tumor immunotherapy, as the focus of scientific research and clinical tumor treatment in
recent years, has received extensive attention. Due to its remarkable curative effect and …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …