As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

Mountainous evidence suggests that inflammation, cardiomyocyte apoptosis and pyroptosis
are involved in the development of sepsis and sepsis-induced cardiomyopathy (SIC) …

The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3)
inflammasome is a component of the inflammatory process, and its aberrant activation is …

Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …

Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is
synthesized as an inactive precursor requiring processing by caspase-1 into an active …