The role of human carboxylesterases in drug metabolism: have we overlooked their importance?
S Casey Laizure, V Herring, Z Hu… - … : The Journal of …, 2013 - Wiley Online Library
Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …
A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
S Oda, T Fukami, T Yokoi, M Nakajima - Drug metabolism and …, 2015 - Elsevier
UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
Recent progress in the discovery of natural inhibitors against human carboxylesterases
DD Wang, LW Zou, Q Jin, J Hou, GB Ge, L Yang - Fitoterapia, 2017 - Elsevier
Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …
Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases
T Fukami, M Kariya, T Kurokawa, A Iida… - European Journal of …, 2015 - Elsevier
Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of
some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly …
some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly …
Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism
YQ Song, Q Jin, DD Wang, J Hou, LW Zou… - Chemico-Biological …, 2021 - Elsevier
Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …
Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity
T Fukami, A Iida, K Konishi, M Nakajima - Biochemical Pharmacology, 2016 - Elsevier
Ketoconazole (KC), an antifungal agent, rarely causes severe liver injury when orally
administered. It has been reported that KC is mainly hydrolyzed to N-deacetyl ketoconazole …
administered. It has been reported that KC is mainly hydrolyzed to N-deacetyl ketoconazole …
Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans
T Yoshida, T Fukami, T Kurokawa, S Gotoh… - European Journal of …, 2018 - Elsevier
Carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes
responsible for the hydrolysis of various clinical drugs. Our recent study demonstrated that …
responsible for the hydrolysis of various clinical drugs. Our recent study demonstrated that …