Optogenetics combines light and genetics to enable precise control of living cells, tissues,
and organisms with tailored functions. Optogenetics has the advantages of …

The light-oxygen-voltage (LOV) domains of phototropins emerged as essential constituents
of light-sensitive proteins, helping initiate blue light-triggered responses. Moreover, these …

Inducible protein switches are currently limited for use in tissues and organisms because
common inducers cannot be controlled with precision in space and time in optically dense …

Cells commonly communicate with each other through diffusible molecules but nonchemical
communication remains elusive. While bioluminescent organisms communicate through …

Cells receive enormous amounts of information from their environment. How they act on this
information—by migrating, expressing genes, or relaying signals to other cells—comprises …

Molecular optogenetics is a highly dynamic research field. In the past two years, the field
was characterized by the development of new allosteric switches as well as the forward …

We describe single-component optogenetic probes whose activation dynamics depend on
both light and temperature. We used the BcLOV4 photoreceptor to stimulate Ras and …

Two‐component systems (TCS) constitute the predominant means by which prokaryotes
read out and adapt to their environment. Canonical TCSs comprise a sensor histidine kinase …

The 24-h cycle of light and darkness governs daily rhythms of complex behaviors across all
domains of life. Intracellular photoreceptors sense specific wavelengths of light that can …

Biomolecular condensates appear throughout cell physiology and pathology, but the
specific role of condensation or its dynamics is often difficult to determine. Optogenetics …