The phosphoinositide 3-kinase (PI3K) pathway plays an integral role in many cellular
processes and is frequently altered in cancer, contributing to tumor growth and survival …

Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

In recent years, important advances have been achieved in the understanding of the
molecular biology of glioblastoma multiforme (GBM); thus, complex genetic alterations and …

Background Significant advances in the molecular profiling of gliomas, led the 2016 World
Health Organization (WHO) Classification to include, for the first-time, molecular biomarkers …

Purpose: The EORTC-26101 study was a randomized phase II and III clinical trial of
bevacizumab in combination with lomustine versus lomustine alone in progressive …

Despite extensive efforts in research and therapeutics, achieving longer survival for patients
with glioblastoma (GBM) remains a formidable challenge. Furthermore, because of rapid …

Background We conducted this meta-analysis based on eligible trials to investigate the
relationship between phosphatase and tensin homolog (PTEN) genetic mutation and glioma …

Glioblastoma (GB) is the more frequent and malignant brain tumour. In spite of all efforts, the
median overall survival of GB patients remains approximately 15 months under therapy. The …

PTEN loss has been associated with poorer prognosis in many solid tumors. However, such
investigation in lymphomas is limited. In this study, PTEN cytoplasmic and nuclear …

MicroRNA-21 (miR-21) is the most consistently over-expressed microRNA (miRNA) in
malignant gliomas. We have previously reported that miR-21 is upregulated in glioma …