Hypertrophic scarring: the greatest unmet challenge after burn injury

CC Finnerty, MG Jeschke, LK Branski, JP Barret… - The Lancet, 2016 - thelancet.com
Improvements in acute burn care have enabled patients to survive massive burns that would
have once been fatal. Now up to 70% of patients develop hypertrophic scars after burns. The …

Keloids: current and emerging therapies

N Ojeh, A Bharatha, U Gaur… - Scars, burns & …, 2020 - journals.sagepub.com
Keloids are pathological scars that grow over time and extend beyond the initial site of injury
after impaired wound healing. These scars frequently recur and rarely regress. They are …

Biodegradable polymeric scaffolds and hydrogels in the treatment of chronic and infectious wound healing

M Pandian, G Reshma, C Arthi, M Másson… - European Polymer …, 2023 - Elsevier
Wound healing is a tightly regulated process, and the presence of bacteria hinders the
process, resulting in infectious wounds. Chronic wounds result in persistent inflammation …

[HTML][HTML] A careob-like nanofibers with a sustained drug release profile for promoting skin wound repair and inhibiting hypertrophic scar

H Zhang, M Guo, T Zhu, H Xiong, LM Zhu - Composites Part B: Engineering, 2022 - Elsevier
Excessive or disordered wound repair results in abnormal hyperplasia of scars, which
intensifies the complexity and difficulty of treatment. The reported wound repair dressings …

Novel insights on understanding of keloid scar: article review

W Mari, SG Alsabri, N Tabal, S Younes, A Sherif… - Journal of the American …, 2015 - Elsevier
Keloid scar, dermal benign fibro-proliferative growth that extends outside the original wound
and invades adjacent dermal tissue due to extensive production of extracellular matrix …

Current advances in hypertrophic scar and keloid management

N Barone, T Safran, J Vorstenbosch… - Seminars in plastic …, 2021 - thieme-connect.com
Hypertrophic scars and keloids are caused by excessive tissue response to dermal injury
due to local fibroblast proliferation and collagen overproduction. This response occurs …

The spectrum of scarring in craniofacial wound repair

HE desJardins-Park, S Mascharak, MS Chinta… - Frontiers in …, 2019 - frontiersin.org
Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-
related morbidity. While scar formation is the normal and inevitable outcome of adult …

Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures

MH Gold, A Andriessen, AC Bhatia… - Journal of cosmetic …, 2020 - Wiley Online Library
Abstract Background Hypochlorous acid (HOCl), a naturally occurring molecule produced by
the immune system, is highly active against bacterial, viral, and fungal microorganisms …

3D printing auxetic architectures for hypertrophic scar therapy

L Chow, K Yick, KH Wong, MS Leung… - Macromolecular …, 2022 - Wiley Online Library
Fitting the human body for different purposes such as flexible electronics and functional
garments can be a challenging task. Pressure garments are used to treat hypertrophic scars …

The effectiveness of pressure therapy (15–25 mmHg) for hypertrophic burn scars: a systematic review and meta-analysis

JW Ai, J Liu, SD Pei, Y Liu, DS Li, H Lin, B Pei - Scientific Reports, 2017 - nature.com
Although pressure therapy (PT) represents the standard care for prevention and treatment of
hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its …