Enzymes in the synthesis of glycoconjugates

RM Schmaltz, SR Hanson, CH Wong - Chemical reviews, 2011 - ACS Publications
Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

Biotechnological production of fucosylated human milk oligosaccharides: Prokaryotic fucosyltransferases and their use in biocatalytic cascades or whole cell …

B Petschacher, B Nidetzky - Journal of Biotechnology, 2016 - Elsevier
Human milk oligosaccharides (HMOs) constitute a class of complex carbohydrates unique to
mother's milk and are strongly correlated to the health benefits of breastfeeding in infants …

[HTML][HTML] Detecting tumor antigen-specific T cells via interaction-dependent fucosyl-biotinylation

Z Liu, JP Li, M Chen, M Wu, Y Shi, W Li, JR Teijaro… - Cell, 2020 - cell.com
Re-activation and clonal expansion of tumor-specific antigen (TSA)-reactive T cells are
critical to the success of checkpoint blockade and adoptive transfer of tumor-infiltrating …

Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies

SS Shivatare, SH Chang, TI Tsai, SY Tseng… - Nature Chemistry, 2016 - nature.com
A new class of broadly neutralizing antibodies (bNAbs) from HIV donors has been reported
to target the glycans on gp120—a glycoprotein found on the surface of the virus envelope …

Cell-based glycan arrays for probing glycan–glycan binding protein interactions

JG Briard, H Jiang, KW Moremen, MS Macauley… - Nature …, 2018 - nature.com
Glycan microarrays provide a high-throughput means of profiling the interactions of glycan-
binding proteins with their ligands. However, the construction of current glycan microarray …

Functional properties, structural studies and chemo-enzymatic synthesis of oligosaccharides

C Zhao, Y Wu, X Liu, B Liu, H Cao, H Yu… - Trends in Food Science …, 2017 - Elsevier
Oligosaccharides offer beneficial effects on immune system and gut health, such as
anticancer activity, immunomodulatory activity, and complement activation. Functional …

A single-step chemoenzymatic reaction for the construction of antibody–cell conjugates

J Li, M Chen, Z Liu, L Zhang, BH Felding… - ACS Central …, 2018 - ACS Publications
Employing live cells as therapeutics is a direction of future drug discovery. An easy and
robust method to modify the surfaces of cells directly to incorporate novel functionalities is …

Efficient biosynthesis of 2′-fucosyllactose using an in vitro multienzyme cascade

C Li, M Wu, X Gao, Z Zhu, Y Li, F Lu… - Journal of Agricultural …, 2020 - ACS Publications
2′-Fucosyllactose (2-FL) is a fucose-containing oligosaccharide that is found in humans
and is believed to have potential nutraceutical and pharmaceutical uses. Here, a promising …

Bioisosteres of carbohydrate functional groups in glycomimetic design

R Hevey - Biomimetics, 2019 - mdpi.com
The aberrant presentation of carbohydrates has been linked to a number of diseases, such
as cancer metastasis and immune dysregulation. These altered glycan structures represent …

Methods for modifying human antibodies by glycan engineering

CH Wong, CY Wu - US Patent 10,087,236, 2018 - Google Patents
(57) ABSTRACT 3, 773, 919 A 3, 896, 111 A 4, 137, 230 A 4, 151, 042 A 4, 248, 870 A 4,
256, 746 A 4, 260, 608 A 4, 265, 814 A 4, 270, 537 A 4, 294, 757 A 4, 307, 016 A 4, 308, 268 …