Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling
plays a significant role. This phenomenon is related to enhanced proliferation of airway …

The extracellular matrix (ECM) provides structural support and imparts a wide variety of
environmental cues to cells. In the past decade, a growing body of work revealed that the …

Fibroblasts differentiate into the highly synthetic and contractile myofibroblast phenotype
when exposed to substrates with an elastic modulus corresponding to pathologically stiff …

Contractile myofibroblasts are responsible for the irreversible alterations of the lung
parenchyma that hallmark pulmonary fibrosis. In response to lung injury, a variety of different …

Abstract 2D surfaces offer simple analysis of cells in culture, yet these often yield different
cell morphologies and responses from those observed in vivo. Considerable effort has …

Genetic mutation and alterations of intracellular signaling have been focused on to
understand the mechanisms of oncogenesis and cancer progression. Currently, it is pointed …

Fibroblast migration is essential to normal wound healing and pathological matrix deposition
in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and …

The extracellular matrix (ECM) determines 3D tissue architecture and provides structural
support and chemical and mechanical cues to the cells. Atomic force microscopy (AFM) has …

Current technologies and available scaffold materials do not support long‐term cell viability,
differentiation, and maintenance of podocytes, the ultra‐specialized kidney resident cells …

Basic in vitro systems can be used to model and assess complex diseases, such as cancer.
Recent advances in this field include the incorporation of multiple cell types and …