Recent trends in miRNA therapeutics and the application of plant miRNA for prevention and treatment of human diseases

AN Saiyed, AR Vasavada, SRK Johar - Future Journal of Pharmaceutical …, 2022 - Springer
Background Researchers now have a new avenue to investigate when it comes to miRNA-
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …

MicroRNAs in glioblastoma multiforme pathogenesis and therapeutics

A Shea, V Harish, Z Afzal, J Chijioke, H Kedir… - Cancer …, 2016 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases

J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …

The role of hypoxia-induced miR-210 in cancer progression

K Dang, KA Myers - International journal of molecular sciences, 2015 - mdpi.com
Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor
development and growth by promoting the formation of a neoplastic environment. The recent …

Integration of miRNA's theranostic potential with nanotechnology: promises and challenges for Parkinson's disease therapeutics

KP Tryphena, G Singh, N Jain, P Famta… - Mechanisms of Ageing …, 2023 - Elsevier
Despite the wide research going on in Parkinson's disease (PD), the burden of PD still
remains high and continues to increase. The current drugs available for the treatment of PD …

Inflamma-microRNAs in Alzheimer's disease: from disease pathogenesis to therapeutic potentials

Y Liang, L Wang - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of senile dementia. Although AD
research has made important breakthroughs, the pathogenesis of this disease remains …

Inhibition of miR-378a-3p by inflammation enhances IL-33 levels: a novel mechanism of alarmin modulation in ulcerative colitis

K Dubois-Camacho, D Diaz-Jimenez… - Frontiers in …, 2019 - frontiersin.org
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa
damage associated with an uncontrolled inflammatory response. This immunological …

RNA therapeutics for improving CAR T-cell safety and efficacy

P Schaible, W Bethge, C Lengerke, RA Haraszti - Cancer research, 2023 - AACR
Autologous chimeric antigen receptor (CAR) T cells have recently emerged as potent tools
in the fight against cancer, with promising therapeutic efficacy against hematological …

Urinary microRNA in kidney disease: Utility and roles

IO Sun, LO Lerman - American Journal of Physiology-Renal …, 2019 - journals.physiology.org
MicroRNAs (miRNAs) are small, noncoding single-stranded RNA oligonucleotides that
modulate physiological and pathological processes by modulating target gene expression …

MicroRNAs associated with the pathogenesis of multiple sclerosis

Q Huang, B Xiao, X Ma, M Qu, Y Li, P Nagarkatti… - Journal of …, 2016 - Elsevier
Multiple sclerosis (MS) is not only an autoimmune disease in which autoreactive immune
cells against myelin damage axons and nerves in the central nervous system, but also a …